abstract：:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...

journal_title：Pancreas

authors： Morioka CY,Saito S,Ohzawa K,Watanabe A

更新日期：2000-03-01 00:00:00

abstract：:Diabetes mellitus secondary to chronic pancreatitis is characterized by a progressive destruction of the pancreas, including loss of the islet cells, leading to a form of diabetes that can mimic both type 1 and type 2 diabetes. Glucagon-like peptide 1(7-36)amide (GLP-1), an intestinally derived insulinotropic hormone,...

journal_title：Pancreas

authors： Hedetoft C,Sheikh SP,Larsen S,Holst JJ

更新日期：2000-01-01 00:00:00

abstract：:This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...

journal_title：Pancreas

authors： Lankisch PG,Pflichthofer D,Lehnick D

更新日期：1999-11-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：:Cryopreservation of pancreatic islets provides many advantages for clinical transplantation. Unfortunately, the freezing and thawing processes lead to a significant loss of islets. In this study, an attempt was made to increase the yield and viability of islets after cryopreservation and thawing. By using canine islet...

journal_title：Pancreas

authors： Arita S,Kasraie A,Une S,Ohtsuka S,Kawahara T,Smith CV,Mullen Y

更新日期：1999-10-01 00:00:00

abstract：:beta-1,4-Galactosyltransferase (GalTase) is the glycosyltransferase in the Golgi apparatus that transfers galactose from UDP-galactose to terminal N-acetylglucosamine residues in glycoconjugates with formation of a beta-1,4 linkage. Neoplasms undergo various changes in the carbohydrate moieties of their glycoconjugate...

journal_title：Pancreas

authors： Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H

更新日期：1999-08-01 00:00:00

abstract：:In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...

journal_title：Pancreas

authors： Morales A,Cuéllar A,Ramírez J,Vilchis F,Díaz-Sánchez V

更新日期：1999-07-01 00:00:00

abstract：:We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...

journal_title：Pancreas

authors： Yamaguchi Y,Matsumura F,Liang J,Okabe K,Matsuda T,Ohshiro H,Ishihara K,Akizuki E,Yamada S,Ogawa M

更新日期：1999-05-01 00:00:00

abstract：:Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...

journal_title：Pancreas

authors： Song M,Zaninovic V,Kim D,Gukovsky I,Gukovskaya A,Kang K,Pandol S

更新日期：1999-04-01 00:00:00

abstract：:We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...

journal_title：Pancreas

authors： Imai Y,Morishita S,Ikeda Y,Toyoda M,Ashizawa T,Yamamoto K,Inoue T,Ishikawa T

更新日期：1999-04-01 00:00:00

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00

abstract：:We diverted bile and pancreatic juice from jejunal blind loops of different lengths in conscious rats to see if the pancreatic secretory response was dependent on the length of the jejunal blind loop. Short-term bile and pancreatic juice diversion from a short jejunal blind loop, representing only 8-10% of the total l...

journal_title：Pancreas

authors： Spannagel AW,Green GM

更新日期：1999-01-01 00:00:00

abstract：:It was reported that free fatty acids degraded from triglycerides by lipase may play a major role in acute necrotizing or hyperlipidemia-induced pancreatitis. We hypothesized that this injury may be related to the peroxidation of cell membrane phospholipids and tested this hypothesis using isolated pancreatic acini. P...

journal_title：Pancreas

authors： Morita Y,Yoshikawa T,Takeda S,Matsuyama K,Takahashi S,Yoshida N,Clemens MG,Kondo M

更新日期：1998-11-01 00:00:00

abstract：:The aim of this study was to document the natural history of chronic hereditary pancreatitis and to compare its evolution to that of chronic alcoholic pancreatitis. Twelve subjects with chronic hereditary pancreatitis were followed up for a mean duration of 15.8 years (range, 1-23) and compared to subjects with chroni...

journal_title：Pancreas

authors： Paolini O,Hastier P,Buckley M,Maes B,Demarquay JF,Staccini P,Bellon S,Caroli-Bosc FX,Dumas R,Delmont J

更新日期：1998-10-01 00:00:00

abstract：:Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...

journal_title：Pancreas

authors： Andersson R,Wang X,Sun Z,Deng X,Soltesz V,Ihse I

更新日期：1998-08-01 00:00:00

abstract：:Amylase inhibition has gastrointestinal and metabolic effects that may aid in the treatment of diabetes and obesity. We tested whether 4 g of a commercially available wheat amylase inhibitor (WAI) affected postprandial carbohydrate (CHO) absorption and plasma glucose or hormones. Twelve persons (four lean and four obe...

journal_title：Pancreas

authors： Lankisch M,Layer P,Rizza RA,DiMagno EP

更新日期：1998-08-01 00:00:00

abstract：:Wheat amylase inhibitor (WAI) was given to growing rats to determine whether chronic inhibition of intraluminal amylase activity alters pancreatic growth, pancreatic enzyme composition, and secretory responsiveness to cholecystokinin octapeptide (CCK-OP) and carbachol. For 21 days 13 rats were fed amylase inhibitor (A...

journal_title：Pancreas

authors： Kataoka K,DiMagno EP

更新日期：1998-07-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...

journal_title：Pancreas

authors： Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

更新日期：1998-05-01 00:00:00

abstract：:We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both se...

journal_title：Pancreas

authors： Oomi K,Amano M

更新日期：1998-04-01 00:00:00

abstract：:In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia t...

journal_title：Pancreas

authors： Konishi Y,Tsutsumi M,Tsujiuchi T

更新日期：1998-04-01 00:00:00

abstract：:Reports of a so-called "mucin-producing tumor of the pancreas" are increasing worldwide. Although the clinicopathologic features and therapeutic strategies of this tumor have been enthusiastically investigated, there are still many unanswered questions regarding this ailment. In this study, problems in the diagnosis a...

journal_title：Pancreas

authors： Kimura W,Kuroda A,Makuuchi M

更新日期：1998-04-01 00:00:00

abstract：:The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...

journal_title：Pancreas

authors： Kitagawa M,Naruse S,Ishiguro H,Hayakawa T

更新日期：1998-04-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：:Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...

journal_title：Pancreas

authors： Crucitti F,Doglietto GB,Frontera D,Viola G,Morganti AG,Valentini V,Alfonsi G,Trodella L,Cellini N

更新日期：1998-01-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity w...

journal_title：Pancreas

authors： Ishiwata T,Bergmann U,Kornmann M,Lopez M,Beger HG,Korc M

更新日期：1997-11-01 00:00:00

abstract：:A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...

journal_title：Pancreas

authors： Kolar C,Caffrey T,Hollingsworth M,Scheetz M,Sutherlin M,Weide L,Lawson T

更新日期：1997-10-01 00:00:00

abstract：:Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...

journal_title：Pancreas

authors： Hosch SB,Knoefel WT,Metz S,Stoecklein N,Niendorf A,Broelsch CE,Izbicki JR

更新日期：1997-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...

journal_title：Pancreas

authors： Kiehne K,Herzig KH,Fölsch UR

更新日期：1997-07-01 00:00:00

abstract：:Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...

journal_title：Pancreas

authors： Lévy P,Lettéron P,Paye F,Molas G,Guimont MC,Pessayre D,Bernades P,Rozé C

更新日期：1997-05-01 00:00:00

abstract：:We examined whether pancreas grafts preserved by the two-layer method maintained adenine nucleotides pool as substrates for ATP synthesis before reperfusion and had the ability to recover pancreatic tissue perfusion and synthesize ATP promptly after reperfusion. After preservation by the two-layer cold storage method ...

journal_title：Pancreas

authors： Kim Y,Kuroda Y,Tanioka Y,Matsumoto S,Fujita H,Sakai T,Hamano M,Suzuki Y,Ku Y,Saitoh Y

更新日期：1997-04-01 00:00:00

abstract：:Although surgical procedures that improve pancreatic drainage alleviate abdominal pain in the vast majority of patients with chronic pancreatitis, postoperative absorption and nutritional status are less predictable. The present study was designed to determine the efficacy of pancreatic enzyme supplementation in maint...

journal_title：Pancreas

authors： Van Hoozen CM,Peeke PG,Taubeneck M,Frey CF,Halsted CH

更新日期：1997-03-01 00:00:00

abstract：:Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Co...

journal_title：Pancreas

authors： Inagaki T,Hoshino M,Hayakawa T,Ohara H,Yamada T,Yamada H,Iida M,Nakazawa T,Ogasawara T,Uchida A,Hasegawa C,Miyaji M,Takeuchi T

更新日期：1997-01-01 00:00:00

abstract：:Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...

journal_title：Pancreas

authors： Conget I,Sarri Y,Somoza N,Vives M,Novials A,Ariza A,Fernández-Alvarez J,Pujol-Borrell R,Gomis R

更新日期：1997-01-01 00:00:00

abstract：:Pancreatic carcinoma is one of the most devastating neoplasms with regard to its resistance to conventional therapy. In a previous report, we found that endogenous tumor necrosis factor (enTNF) exerts an intracellular protective effect against exogenous TNF- and Adriamycin (ADM)-induced cytotoxicity by scavenging oxyg...

journal_title：Pancreas

authors： Watanabe N,Tsuji N,Tsuji Y,Sasaki H,Okamoto T,Akiyama S,Kobayashi D,Sato T,Yamauchi N,Niitsu Y

更新日期：1996-11-01 00:00:00

abstract：:The effect of a potent and long-acting bradykinin B2-receptor antagonist (HOE140) on acute pancreatitis induced by retrograde infusion of trypsin and taurocholate into the pancreatic duct was studied in rats. HOE140 was administered subcutaneously immediately before and 3 h after the induction of pancreatitis and the ...

journal_title：Pancreas

authors： Kanbe T,Naruse S,Kitagawa M,Nakae Y,Hayakawa T

更新日期：1996-10-01 00:00:00

abstract：:In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...

journal_title：Pancreas

authors： Hadac EM,Ghanekar DV,Holicky EL,Pinon DI,Dougherty RW,Miller LJ

更新日期：1996-08-01 00:00:00

abstract：:The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...

journal_title：Pancreas

authors： Friess H,Malfertheiner P,Isenmann R,Kühne H,Beger HG,Büchler MW

更新日期：1996-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha) has been implicated as one of the numerous likely mediators of the systemic complications of acute pancreatitis. Recent suggestions that calcium (Ca2+) acts as a signal not only for TNF alpha release but also for TNF alpha action at distant sites led us to hypothesize that the c...

journal_title：Pancreas

authors： Hughes CB,el-Din AB,Kotb M,Gaber LW,Gaber AO

更新日期：1996-07-01 00:00:00

abstract：:The association between acute pancreatitis and severe hypertriglyceridemia has long been recognized. We report two cases of severe primary hypertriglyceridemia (types 1 and V) with recurrent acute pancreatitis. In both patients, observance of appropriate diet and drug therapy was insufficient. Recurrent episodes of pa...

journal_title：Pancreas

authors： Piolot A,Nadler F,Cavallero E,Coquard JL,Jacotot B

更新日期：1996-07-01 00:00:00

abstract：:Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...

journal_title：Pancreas

authors： Berry SM,Fink AS

更新日期：1996-05-01 00:00:00